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Statistical analyses were performed using IBM SPSS software, with significance set at p 0.05)

Because of this, certain groups may want to exercise caution or avoid these supplements altogether: People taking hormone-related or other prescription medications Ingredients in hormone-support supplements may interact with treatments such as hormone replacement therapy (HRT), birth control, diabetes medications, thyroid hormones, immunosuppressants, antihypertensives, sedatives, and others.35 These interactions can alter how medications work or increase the risk of side effects

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Gradual dose escalation, as described in the timing section above, gives the gut time to adapt to berberine before reaching therapeutic doses